In this paper we present the methodology of data collection and implementation of databases for the creation of extensive lexical and terminological resources for the Greek Sign Language (GSL) in order to introduce the major issue of dynamic sign representation. In respect to electronic linguistic resources of GSL, the focus is on issues of validation of linguistic content, multipurpose design and reusability of created resources, exemplified by the multimedia dictionary products of the projects NOEMA (1999-2001) and PROKLISI (2002-2004). In relation to sign representation, we discuss the use of video as a restricted means of reproducing linguistic content uttered in the three-dimensional space and present an attempt to use avatar and animation technologies, along with exploitation of electronic linguistic resources of the Greek Sign Language (GSL), in order to provide a dynamic device of generating unrestricted sign sequences. The aim is to set up a sign generation mechanism for the Greek Sign Language by means of a virtual human signer (avatar) that can be adaptable to various platforms. The overall emphasis is placed on exploitation of Universal Access and Design for All principles that allow proactive system architectures instead of a-posteriori adaptations